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Antagonistic Pleiotropy, Reversal of Dominance, and Genetic-Polymorphism

Curtsinger, Jw and Service, Pm and Prout, T (1994) Antagonistic Pleiotropy, Reversal of Dominance, and Genetic-Polymorphism. American Naturalist, 144 (2). pp. 210-228. ISSN 1537-5323

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Publisher’s or external URL: http://dx.doi.org/10.1086/285671

Abstract

Conditions for polymorphism at pleiotropic loci with antagonistic effects on fitness components are investigated, under the assumptions of additivity and multiplicativity of fitness components. We show that the conditions for stable polymorphism are rather restrictive, especially with weak selection. The conditions are also very sensitive to the dominance parameters; in particular, reversal of dominance is often required for stable polymorphism. A review Of biochemical mechanisms of dominance suggests that dominance reversal is not likely to be common. The conditions for maintaining genetic variation at two antagonistic and pleiotropic loci are even more restrictive than for the one-locus case. When conditions for stable polymorphism by antagonistic pleiotropy are satisfied, substantial dominance variance in one or both fitness components is expected but is seldom observed in experiments. Antagonistic pleiotropy implies stabilizing selection on the fitness components separately, which usually tends to reduce genetic variance. We conclude that, even though trade-offs in fitness components may be common, antagonistic pleiotropy probably plays a limited role in explaining the persistence of genetic variation in fitness components.

Item Type: Article
Publisher’s Statement: ©1994 The University of Chicago Press for The American Society of Naturalists
ID number or DOI: 10.1086/285671
Keywords: drosophila-melanogaster; fitness components; laboratory evolution; natural-selection; populations; quantitative genetics; senescence; Variability; variance; viability
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
NAU Depositing Author Academic Status: Faculty/Staff
Department/Unit: College of Engineering, Forestry, and Natural Science > Biological Sciences
Date Deposited: 29 Sep 2015 21:57
URI: http://openknowledge.nau.edu/id/eprint/67

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