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Chronic Cold Exposure Increases Skeletal Muscle Oxidative Structure and Function in Monodelphis domestica, a Marsupial Lacking Brown Adipose Tissue

Schaeffer, P. J. and Villarin, J. J. and Lindstedt, S. L. (2003) Chronic Cold Exposure Increases Skeletal Muscle Oxidative Structure and Function in Monodelphis domestica, a Marsupial Lacking Brown Adipose Tissue. Physiological and Biochemical Zoology, 76 (6). pp. 877-887. ISSN 1537-5293

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Publisher’s or external URL: http://dx.doi.org/10.1086/378916

Abstract

Monodelphis domestica (Marsupialia: Didelphidae) was used as a model animal to investigate and compare muscle adaptation to exercise training and cold exposure. The experimental treatment consisted of four groups of animals: either warm or cold acclimation temperature and with or without endurance exercisetraining. Maximal aerobic capacity during a running Vo2max test in the warm-exercised or cold-exposed (with or without without exercise) groups was about 130 mL O2/kg/min, significantlyhigher than the warm-acclimated controls at 113.5mL O2/kg/min. Similarly, during an acute cold challenge (Vo2summit ), maximal aerobic capacity was higher in these three experimental groups at ∼95 mL O2/kg/min compared with 80.4mL O2/kg/min in warm-acclimated controls. Respiratory exchange ratio was significantly lower (0.89-0.68), whereas relative heart mass 0.52%-0.73%) and whole-body muscle mitochondrialvolume density (2.59 to 3.04 cm[sup3]) were significantly higher following cold exposure. Chronic cold exposure was a stronger stimulus than endurance exercise training for tissue specific adaptations. Although chronic cold exposure and enduranceexercise are distinct challenges, physiological adaptations to each overlap such that the capacities for aerobic performance in response to both cold exposure and running are increased by either or both treatments.

Item Type: Article
Publisher’s Statement: Copyright 2003 by The University of Chicago. All rights reserved.
ID number or DOI: 10.1086/378916
Keywords: cold exposure; muscle mass; skeletal muscle; adaptation;
Subjects: Q Science > QH Natural history > QH301 Biology
NAU Depositing Author Academic Status: Faculty/Staff
Department/Unit: College of Engineering, Forestry, and Natural Science > Biological Sciences
Date Deposited: 18 Oct 2015 20:12
URI: http://openknowledge.nau.edu/id/eprint/1758

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