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The personal human oral microbiome obscures the effects of treatment on periodontal disease

Schwarzberg, Karen and Le, Rosalin and Bharti, Balambal and Lindsay, Suzanne and Casaburi, Giorgio and Salvatore, Francesco and Saber, Mohamed H. and Alonaizan, Faisal and Slots, Jørgen and Gottlieb, Roberta A. and Caporaso, J. Gregory and Kelley, Scott T. (2014) The personal human oral microbiome obscures the effects of treatment on periodontal disease. PLoS ONE, 9 (1). e86708. ISSN 1932-6203

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Publisher’s or external URL: http://dx.doi.org/10.1371/journal.pone.0086708


Periodontitis is a progressive disease of the periodontium with a complex, polymicrobial etiology. Recent Next-Generation Sequencing (NGS) studies of the microbial diversity associated with periodontitis have revealed strong, community-level differences in bacterial assemblages associated with healthy or diseased periodontal sites. In this study, we used NGS approaches to characterize changes in periodontal pocket bacterial diversity after standard periodontal treatment. Despite consistent changes in the abundance of certain taxa in individuals whose condition improved with treatment, post-treatment samples retained the highest similarity to pre-treatment samples from the same individual. Deeper phylogenetic analysis of periodontal pathogen-containing genera Prevotella and Fusobacterium found both unexpected diversity and differential treatment response among species. Our results highlight how understanding interpersonal variability among microbiomes is necessary for determining how polymicrobial diseases respond to treatment and disturbance.

Item Type: Article
ID number or DOI: 10.1371/journal.pone.0086708
Keywords: Adult; Anti-Bacterial Agents; bacteria; Bacterial pathogens; Biological data management; Biology; Case-Control Studies; Computational biology; Dentistry; diversity; Fusobacterium; Genome databases; Genomics; High-Throughput Nucleotide Sequencing; Host-parasite relationships; Host-pathogen interaction; Humans; Indians, North American; Medical microbiology; Medicine; Microbial pathogens; Microbiology; microbiota; Oral diseases; Oral medicine; Periodontitis; Periodontium; Phylogeny; Prevotella; public health; public health research; Research Article; Sequence analysis; sequences; Severity of Illness Index; taxonomy; therapy; treatment
Subjects: Q Science > QR Microbiology
NAU Depositing Author Academic Status: Faculty/Staff
Department/Unit: College of Engineering, Forestry, and Natural Science > Biological Sciences
Research Centers > Center for Microbial Genetics and Genomics
Date Deposited: 16 Oct 2015 19:25
URI: http://openknowledge.nau.edu/id/eprint/1696

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