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An attenuated strain of Bacillus anthracis (CDC 684) has a large chromosomal inversion and altered growth kinetics

Okinaka, Richard T and Price, Erin P. and Wolken, Spenser R. and Gruendike, Jeffrey M. and Chung, Wai K. and Pearson, Talima and Xie, Gary and Munk, Chris and Hill, Karen K. and Challacombe, Jean and Ivins, Bruce E. and Schupp, James M. and Beckstrom-Sternberg, Stephen M. and Friedlander, Arthur and Keim, Paul (2011) An attenuated strain of Bacillus anthracis (CDC 684) has a large chromosomal inversion and altered growth kinetics. BMC Genomics, 12 (1). p. 477. ISSN 1471-2164

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Publisher’s or external URL: http://dx.doi.org/10.1186/1471-2164-12-477


An isolate originally labeled Bacillus megaterium CDC 684 was found to contain both pXO1 and pXO2, was non-hemolytic, sensitive to gamma-phage, and produced both the protective antigen and the poly-D-glutamic acid capsule. These phenotypes prompted Ezzell et al., (J. Clin. Microbiol. 28:223) to reclassify this isolate to Bacillus anthracis in 1990. PMID: 21962024

Item Type: Article
Publisher’s Statement: © 2011 Okinaka et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ID number or DOI: 10.1186/1471-2164-12-477
Keywords: Animal Models of Human Diseases (VV400) (New March 2000); Animals; Anthrax; attenuation; Bacillaceae; Bacillales; Bacilli; Bacillus anthracis; Bacillus (Bacteria); Bacillus megaterium; bacteria; bacterial antigens; bacterium; Base Sequence; Cavia; Caviidae; cereus; Chordata; Chromosome Inversion; Chromosomes; disease models; DNA sequences; escherichia-coli; eukaryotes; experimental infections; expression; Firmicutes; General Molecular Biology (ZZ360) (Discontinued March 2000); Genetics and Molecular Biology of Microorganisms (ZZ395) (New March 2000); Genome analysis; Genome, Bacterial; Genomes; growth; guinea pigs; guineapigs; Index Medicus; inhalation anthrax; mammals; Microbial Life Cycles (ZZ396) (New March 2000); molecular-cloning; Molecular Sequence Data; nucleotide sequences; Phylogeny; Polymorphism, Single Nucleotide; Prion, Viral, Bacterial and Fungal Pathogens of Animals (LL821) (New March 2000); Prokaryotes; protective antigen gene; protective antigens; recombination; Replication; rodents; sequence; strains; toxin genes; Vertebrates; viral replication; virulence
Subjects: Q Science > QH Natural history > QH426 Genetics
NAU Depositing Author Academic Status: Faculty/Staff
Department/Unit: Research Centers > Center for Microbial Genetics and Genomics
Date Deposited: 30 Sep 2015 20:28
URI: http://openknowledge.nau.edu/id/eprint/472

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