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Replacement of the phosphodiester linkage in DNA with sulfamide and 3 '-N-sulfamate groups

Fettes, K. J. and Howard, N. and Hickman, D. T. and Adah, S. A. and Player, M. R. and Torrence, Paul F. and Micklefield, J. (2000) Replacement of the phosphodiester linkage in DNA with sulfamide and 3 '-N-sulfamate groups. Chemical Communications (9). pp. 765-766. ISSN 1364-548X


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Publisher’s or external URL: http://dx.doi.org/10.1039/b001586p


Replacing phosphodiester linkages in DNA with neutral 3'-N-sulfamate groups has little effect on the binding affinity for complementary DNA or RNA, whereas incorporation of sulfamide groups into DNA results in considerable destabilisation of isosequential duplexes.

Item Type: Article
Publisher’s Statement: Published by The Royal Society of Chemistry.
ID number or DOI: 10.1039/b001586p
Keywords: duplex; Inhibitors; Oligonucleotides
Subjects: Q Science > QH Natural history > QH426 Genetics
NAU Depositing Author Academic Status: Faculty/Staff
Department/Unit: College of Engineering, Forestry, and Natural Science > Chemistry and Biochemistry
Date Deposited: 30 Sep 2015 22:42
URI: http://openknowledge.nau.edu/id/eprint/551

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