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Development and optimization of an injectable liquid-to-solid polymer gelation system for treatment of large and wide-neck intracranial aneurysms

Merritt, William Christopher (2021) Development and optimization of an injectable liquid-to-solid polymer gelation system for treatment of large and wide-neck intracranial aneurysms. Doctoral thesis, Northern Arizona University.

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An intracranial aneurysm is an abnormal enlargement or pouch that forms from a weakened vessel segment in the brain. Often going unnoticed and untreated, these aneurysms can rupture and cause a sudden and catastrophic hemorrhagic stroke. Approximately 15% of patients die from an intracranial aneurysm rupture even before receiving medical attention and 25% of patients die despite medical treatment. Patients that survive typically suffer from various levels of morbidity such as neurological deficits. Thus, only one in four patients who suffer a ruptured intracranial aneurysm will fully recover. It is estimated that between 3 million and 6 million Americans have intracranial aneurysms, and approximately 30,000 people in the United States suffer a rupture event each year.1–6There are a number of endovascular aneurysm treatment devices currently on the market, as well as a few more under investigation. However, all of these devices have significant shortcomings such as limited biocompatibility and efficacy that can potentially be addressed with a new device or devices. This proposal details the development of a novel liquid embolic (PPODA-QT) that quickly solidifies into a stable and biocompatible cast of any aneurysm shape and size. This material could provide surgeons with a novel approach for aneurysm treatment, especially for large and wide-neck aneurysms that current devices have limited efficacy in treating. Preliminary in vitro modeling and in vivo aneurysm studies have demonstrated that PPODA-QT allows for precise delivery control, vessel protection, and complete and durable occlusion of larger side-wall and bifurcation aneurysms with small-, medium-, and wide-necks, while eliminating the issues encountered with past liquid embolics like Onyx such as biocompatibility, device migration during delivery, and catheter adhesion.1,7,8 Gross and histological evaluation of PPODA-QT injected into in vivo aneurysm models has also suggested that the material is highly biocompatible, making PPODA-QT an exciting material candidate for endovascular intracranial aneurysm treatment.1

Item Type: Thesis (Doctoral)
Publisher’s Statement: © Copyright is held by the author. Digital access to this material is made possible by the Cline Library, Northern Arizona University. Further transmission, reproduction or presentation of protected items is prohibited except with permission of the author.
Keywords: Intracranial Aneurysms; Liquid Embolics; Neurointervention
Subjects: R Medicine > RB Pathology
MeSH Subjects: E Analytical,Diagnostic and Therapeutic Techniques and Equipment > E02 Therapeutics
NAU Depositing Author Academic Status: Student
Department/Unit: Graduate College > Theses and Dissertations
College of Engineering, Informatics, and Applied Sciences > Mechanical Engineering
Date Deposited: 03 Feb 2022 19:03
Last Modified: 03 Feb 2022 19:03
URI: https://openknowledge.nau.edu/id/eprint/5644

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