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Q fever epidemic in Hungary, April to July 2013

Gyuranecz, M. and Sulyok, K. M. and Balla, E. and Mag, T. and Balazs, A. and Simor, Z. and Denes, B. and Hornok, S. and Bajnoczl, P. and Hornstra, H. M. and Pearson, T. and Keim, P. and Dan, A. (2014) Q fever epidemic in Hungary, April to July 2013. Eurosurveillance, 19 (30). 5 pp.. ISSN 1560-7917


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We investigated a Q fever outbreak with human patients showing high fever, respiratory tract symptoms, headache and retrosternal pain in southern Hungary in the spring and summer of 2013. Seventy human cases were confirmed by analysing their serum and blood samples with micro-immunofluorescence test and real-time PCR. The source of infection was a merino sheep flock of 450 ewes, in which 44.6% (25/56) seropositivity was detected by enzyme-linked immunosorbent assay. Coxiella burnetii DNA was detected by real-time PCR in the milk of four of 20 individuals and in two thirds (41/65) of the manure samples. The multispacer sequence typing examination of C. burnetii DNA revealed sequence type 18 in one human sample and two manure samples from the sheep flock. The multilocus variable-number tandem repeat analysis pattern of the sheep and human strains were also almost identical, 4/5-9-3-3-0-5 (Ms23-Ms24-Ms27-Ms28-Ms33-Ms34). It is hypothesised that dried manure and maternal fluid contaminated with C. burnetii was dispersed by the wind from the sheep farm towards the local inhabitants. The manure was eliminated in June and the farm was disinfected in July. The outbreak ended at the end of July 2013.

Item Type: Article
Publisher’s Statement: Published by: European Centre for Disease Prevention and Control.
Keywords: coxiella-burnetii; Netherlands; outbreak; Sheep; ticks
Subjects: R Medicine > RA Public aspects of medicine
NAU Depositing Author Academic Status: Faculty/Staff
Department/Unit: College of Engineering, Forestry, and Natural Science > Biological Sciences
Research Centers > Center for Microbial Genetics and Genomics
Date Deposited: 30 Sep 2015 17:58
URI: http://openknowledge.nau.edu/id/eprint/570

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