In vitro neurovascular model development for liquid embolic implant simulation

Settanni, Christopher Emil (2021) In vitro neurovascular model development for liquid embolic implant simulation. Masters thesis, Northern Arizona University.

Text Settanni_2021_vitro_neurovascular_model_development_liquid_embolic_imp.pdf - Published Version Restricted to Repository staff only Download (8MB) | Request a copy

Abstract

Cerebral aneurysms are responsible for the death of 500,000 people each year with half of the victims less than 50 years old.1 Aneurysm rupture results in 50% mortality and a 66% chance of permanent disability. Current aneurysm treatment devices are delivered by making an incision in the femoral artery of a patient, and delivered to the brain using microcatheters. A novel liquid embolic device, PPODA-QT poly (propylene glycol) diacrylate and pentaerythritol tetrakis (3-mercaptopropionate) (PPODA-QT), is under development for the occlusion and treatment of cerebral aneurysms. Benchtop testing may be utilized to augment in vivo biocompatibility tests.The first aim of this thesis involved the creation of a vessel phantom that mimics the physiological properties and tortuosity of human vasculature. In the second aim, a flow loop was designed to replicate and monitor physiological flows within the circle of Willis. In the last aim, the resultant system was utilized to monitor a simulated balloon occlusion and long term data acquisition. A clinically relevant SolidWorks® model of human vasculature was designed. A biomimetic material, printed using a Connex® 3 Objet 260 printer, was selected to match human vessel properties. An in vitro model was created, using a ViVitro® Superpump and LabVIEW® VI with sensors to monitor pressure and flow. Lastly, a simulated use in a mock procedure and long term monitoring evaluation were performed. This thesis presents a methodology of developing and adapting an in vitro flow loop for clinical simulation and empirical procedural validation.

Item Type:	Thesis (Masters)
Publisher’s Statement:	© Copyright is held by the author. Digital access to this material is made possible by the Cline Library, Northern Arizona University. Further transmission, reproduction or presentation of protected items is prohibited except with permission of the author.
Keywords:	aneurysm model; balloon occlusion; clinical simulation; flow loop; in vitro model; liquid embolic
Subjects:	R Medicine > R Medicine (General)
NAU Depositing Author Academic Status:	Student
Department/Unit:	Graduate College > Theses and Dissertations College of Engineering, Informatics, and Applied Sciences > Mechanical Engineering
Date Deposited:	07 Jul 2022 21:05
Last Modified:	07 Jul 2022 21:05
URI:	https://openknowledge.nau.edu/id/eprint/5817

Actions (login required)

IR Staff Record View

Downloads