Assessing the association of ten-year cardiovascular disease risk with depression in the national health and nutrition examination surveys

Struve, Gabrielle Christine (2021) Assessing the association of ten-year cardiovascular disease risk with depression in the national health and nutrition examination surveys. Masters thesis, Northern Arizona University.

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Abstract

Major depressive disorder and cardiovascular diseases (CVD) are two of the leading causes of disability worldwide and CVD is the leading cause of death in the US. There is strong evidence that depression is associated with increased risk of initial CVD events and thus it is important to quantify CVD risk by depression status in persons free of clinical CVD. Extant literature characterizing this association is limited by heterogeneous and suboptimal assessments of both depression and CVD risk, hindering prevention and treatment. In particular, almost no studies to date have examined the depression/CVD risk association using contemporary, ecologically valid depression and CVD risk assessments. The objective of this study was to evaluate the association between depression, measured by the Patient Health Questionnaire-9 (PHQ-9), with CVD risk, as measured by the pooled cohort equations, in a national sample of U.S. adults. In sex-specific analyses, depression was consistently associated with higher 10-year ASCVD risk for women, with observed ten-year risk 1-3% higher for depressed women. However, depression was associated with higher ASCVD risk for men 40-49 years of age but not associated with ASCVD risk in older groups. These findings may be useful for identifying comorbid CVD risk when screening for depression and determining appropriate risk reduction strategies for depressed persons, particularly women, who are at elevated medium-term risk for clinical CVD.Keywords: depression, ASCVD risk, PHQ-9, risk factors, cardiovascular disease, assessment

Item Type:	Thesis (Masters)
Publisher’s Statement:	© Copyright is held by the author. Digital access to this material is made possible by the Cline Library, Northern Arizona University. Further transmission, reproduction or presentation of protected items is prohibited except with permission of the author.
Keywords:	ASCVD risk; Assessment; Cardiovascular Disease; Depression; PHQ-9; Risk Factors
Subjects:	B Philosophy. Psychology. Religion > BF Psychology
NAU Depositing Author Academic Status:	Student
Department/Unit:	Graduate College > Theses and Dissertations College of Social and Behavioral Science > Psychological Sciences
Date Deposited:	13 Jul 2022 16:11
Last Modified:	14 Jul 2022 08:30
URI:	https://openknowledge.nau.edu/id/eprint/5821

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