Creating commercial models of delayed aneurysm rupture after flow-diverter treatment

Sodawalla, Husain Mustansir (2023) Creating commercial models of delayed aneurysm rupture after flow-diverter treatment. Doctoral thesis, Northern Arizona University.

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Abstract

Giant intracranial aneurysms (GIAs) are not only some of the most difficult aneurysms to treat but are extremely vulnerable to rupture (50-60%). Even treatments deemed successful in the short-term allow for the mechanically unstable clot (thrombus) to form and reopen the aneurysm dome (recanalization), resulting in Delayed Aneurysm Rupture (DAR) about 20% of the time within 12 months of treatment. The current solution of deploying metal coils in the aneurysm or flow diverters across the aneurysm neck does not meet two clinically vital needs: aneurysmal neck protection and decrease in intra-aneurysmal thrombus formation. The latest medical devices for DAR studies require a commercially available, predictable in vitro model for accurately simulating and testing the long-term effectiveness of GIA treatment. The goal of this project is to develop a commercial model for current and future testing of flow diverters, coils, and other embolic devices for effective reduction of DAR. We developed a novel bench-top (in vitro) aneurysmal rupture model utilizing the recent advancements in 3D-print technology (Aim 1) and evaluate the anti-rupture protection ability of a new embolic device (NeuroCURE™) and compared it to current coil and flow diverter treatments (Aim 2). NeuroCURE™ is currently under FDA investigational device exemption (IDE) consideration as a new device for treating larger, wide-neck aneurysms. The model can be used to support institutional research efforts, industry medical device developments efforts, and clinical patient training efforts. The anatomically, physiologically, and pathologically relevant comprehensive model system may reduce the need for complex animal (in vivo) models – which currently cannot be used to create consistent and repeatable in vivo GIA models.

Item Type:	Thesis (Doctoral)
Publisher’s Statement:	© Copyright is held by the author. Digital access to this material is made possible by the Cline Library, Northern Arizona University. Further transmission, reproduction or presentation of protected items is prohibited except with permission of the author.
Keywords:	3D printing; Aneurysm; Flow Diverter; In vitro Model; Medical Device; Rupture
Subjects:	R Medicine > R Medicine (General)
MeSH Subjects:	J Technology,Industry,Agriculture > J01 Technology, Industry, and Agriculture
NAU Depositing Author Academic Status:	Student
Department/Unit:	Graduate College > Theses and Dissertations College of Engineering, Informatics, and Applied Sciences > Mechanical Engineering
Date Deposited:	29 Jul 2026 17:46
Last Modified:	29 Jul 2026 17:46
URI:	https://openknowledge.nau.edu/id/eprint/6325

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