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Tularemia in Alaska, 1938-2010

Hansen, Cristina M. and Vogler, Amy J. and Keim, Paul and Wagner, David M. and Hueffer, Karsten (2011) Tularemia in Alaska, 1938-2010. Acta Veterinaria Scandinavica, 53 (61). ISSN 1751-0147

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Publisher’s or external URL: http://dx.doi.org/10.1186/1751-0147-53-61


Tularemia is a serious, potentially life threatening zoonotic disease. The causative agent, Francisella tularensis, is ubiquitous in the Northern hemisphere, including Alaska, where it was first isolated from a rabbit tick (Haemophysalis leporis-palustris) in 1938. Since then, F. tularensis has been isolated from wildlife and humans throughout the state. Serologic surveys have found measurable antibodies with prevalence ranging from < 1% to 50% and 4% to 18% for selected populations of wildlife species and humans, respectively. We reviewed and summarized known literature on tularemia surveillance in Alaska and summarized the epidemiological information on human cases reported to public health officials. Additionally, available F. tularensis isolates from Alaska were analyzed using canonical SNPs and a multi-locus variable-number tandem repeats (VNTR) analysis (MLVA) system. The results show that both F. t. tularensis and F. t. holarctica are present in Alaska and that subtype A.I, the most virulent type, is responsible for most recently reported human clinical cases in the state.

Item Type: Article
ID number or DOI: 10.1186/1751-0147-53-61
Keywords: francisella-tularensis; molecular epidemiology; mosquitos; pathogens; serologic survey; transmission; wolves
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology
NAU Depositing Author Academic Status: Faculty/Staff
Department/Unit: College of Engineering, Forestry, and Natural Science > Biological Sciences
Date Deposited: 30 Sep 2015 05:22
URI: http://openknowledge.nau.edu/id/eprint/275

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