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Characterization of injectable liquid embolic particles

Cotter, Trevor Robert (2018) Characterization of injectable liquid embolic particles. Masters thesis, Northern Arizona University.

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Cerebral aneurysms can be found in over 2% of the American population, and their rupture into hemorrhagic stroke carries a 40% mortality rate. This makes their treatment important to clinicians trying to prevent this from happening to millions of people. A novel polymer, poly(propylene glycol) diacrylate and pentaerythritol tetrakis (3-mercaptopropionate) (PPODA-QT), has been developed in order to successfully embolize these aneurysms. It is injected through a catheter into the aneurysm, where it cures and the aneurysm can heal itself, eliminating the risk of rupture and stroke. This thesis focuses on the embolic risks presented during the injection and curing of PPODA-QT. The first aim of this project was to build an endovascular flow model that could accurately mimic conditions found in the human body. This was used to practice procedures and evaluate embolic risk. In the second aim, multiple microscopy methods were used to capture and analyze particles shed downstream during the procedure to ensure that the injection would be safe for use in living models. In the final aim, rabbit aneurysm models were used to confirm that no negative embolic effects were observed. A model was built that could control pressure, temperature, and pressure. The model was designed with customizable inserts that could be changed to model various anatomies. Differential interference contrast (DIC) microscopy was used to analyze filters that captured downstream particles produced during the procedure. Feasibility of inline digital holography was also performed. Finally, a rabbit aneurysm model was developed in order to treat different aneurysm morphologies. This thesis presents a series of methods that can be used to study of the embolic risks of a novel aneurysm treatment with the potential to impact millions of lives.

Item Type: Thesis (Masters)
Publisher’s Statement: © Copyright is held by the author. Digital access to this material is made possible by the Cline Library, Northern Arizona University. Further transmission, reproduction or presentation of protected items is prohibited except with permission of the author.
Keywords: aneurysm; brain; embolic; endovascular; neurovascular; stroke
Subjects: Q Science > QC Physics
NAU Depositing Author Academic Status: Student
Department/Unit: Graduate College > Theses and Dissertations
College of the Environment, Forestry, and Natural Sciences > Physics and Astronomy
Date Deposited: 29 Mar 2019 20:36
URI: http://openknowledge.nau.edu/id/eprint/5417

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