Development of a novel balloon-mesh device to improve the embolization of aneurysms

Asgari, Omid (2023) Development of a novel balloon-mesh device to improve the embolization of aneurysms. Doctoral thesis, Northern Arizona University.

Text Asgari_2023_development_novel_balloon-mesh_device_improve_embolization.pdf - Published Version Download (7MB)

Abstract

The rupture of an intracranial aneurysm is the cause of death for 500,000 people each year, with half of them being younger than 50 years old. It is estimated that 3-6 million Americans harbor a brain aneurysm and thus are at risk from this condition. While the neurointerventional field has progressed dramatically over the past few years, existing embolization devices suffer from significant limitations. Major challenges to successful treatment of brain aneurysms of varying sizes and geometries include ensuring the aneurysm sac remains occluded in the long-term (reducing recanalization risk) while avoiding downstream thrombus and subsequent ischemia. A supporting medical device that can improve the efficiency of aneurysm treatment, without significantly affecting parent artery blood flow, is needed. The purpose of this translational research is to develop and validate an endovascular device – Balloon-Mesh – which improves aneurysm neck protection during embolic device placement and reduces blood flow obstruction in the parent artery, thereby minimizing ischemic risk. This project includes two aims. Aim I, a design, validate, and manufacture a new prototype w. Aim II, test the efficacy of the prototypes as in an in-vitro model and compared to current commercial devices. The prototypes were be delivered to our portable blood flow system utilizing simulated neurointerventional surgical techniques under fluoroscopic imaging, coordinated by the Bioengineering Devices Lab (BDL) at NAU. This device has the potential to alleviate current time constraints imposed by temporary balloon protection, provide a smooth surface at the aneurysm neck for consistent device placement, eliminate ischemic effects distal to the parent artery, and minimize intra-aneurysmal flow remnants pre- and post-treatment.

Item Type:	Thesis (Doctoral)
Publisher’s Statement:	© Copyright is held by the author. Digital access to this material is made possible by the Cline Library, Northern Arizona University. Further transmission, reproduction or presentation of protected items is prohibited except with permission of the author.
Keywords:	Intracranial aneurysm; Neurointerventional; Embolization devices; Medical technology
Subjects:	R Medicine > RD Surgery
MeSH Subjects:	E Analytical,Diagnostic and Therapeutic Techniques and Equipment > E04 Surgical Procedures, Operative
NAU Depositing Author Academic Status:	Student
Department/Unit:	Graduate College > Theses and Dissertations College of Engineering, Informatics, and Applied Sciences > Mechanical Engineering
Date Deposited:	23 Oct 2025 18:01
Last Modified:	23 Oct 2025 18:01
URI:	https://openknowledge.nau.edu/id/eprint/6269

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